File:Microbiota-derived 3-Indolepropionic acid.svg
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English: This diagram shows the metabolism of tryptophan to indole and indole derivatives in the colonic lumen. absorption and Lactobacillus species metabolize indole into indole-3-aldehyde (I3A) which acts on the intestinal L cells and as a ligand for AhR. Indole can also be metabolized by the liver to indoxyl sulfate, a compound that is detrimental to human health in high concentrations. Accumulation of indoxyl sulfate in blood plasma is toxic and associated with vascular disease and renal dysfunction. AST-120 (adsorbs indole, in turn decreasing the concentration of indoxyl sulfate in blood plasma. |
| Date | |
| Source | Re-drawn from File:Microbiota-derived_3-Indolepropionic_acid.jpg; (April 2016). "PMID Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease |
| Author | User:Slashme, Zhang LS, Davies SS |
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■ File:Microbiota-derived 3-Indolepropionic acid-notext.svg ■ File:Microbiota-derived 3-Indolepropionic acid.jpg |
| SVG development |  This diagram uses embedded text that can be easily translated using a text editor. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 705 × 552 (119 KB) | Slashme (talk | contribs) | Fix kerning issues | ||
| 705 × 552 (144 KB) | Slashme (talk | contribs) | {{Information |Description ={{en|1=coming soon}} |Source =Re-drawn from File:Microbiota-derived_3-Indolepropionic_acid.jpg |Author =User:Slashme |Date =2017-11-01 |Permission = |other_versions =[[:File:Microbio... |
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