Indiana vs. Notre Dame odds, prediction: College Football Playoff pick, best bet

The Notre Dame Fighting Irish find themselves as the Goliath against the Indiana Hoosiers’ David in the first round of the College Football Playoff.

No. 7 Notre Dame comes in as a 7.5-point favorite at Fanatics Sportsbook and is -285 on the moneyline to advance to the second round, where the winner will face second-seeded Georgia.

Unlike most of the other college football bowl games, there will be no significant opt-outs or transfer portal players here.

Indiana vs. Notre Dame odds

Team	Spread	Moneyline	Total
Indiana	+7.5 (-115)	+230	Over 51.5 (-110)
Notre Dame	-7.5 (-105)	-285	Under 51.5 (-110)

Indiana vs. Notre Dame prediction

Friday, Dec. 20, 8 p.m. ET, ABC/ESPN

Temperatures for this game, which will be played in South Bend, Ind., are expected to be in the 20s with wind gusts upwards of 15 mph.

Snow showers are also in the forecast, so snow could be a significant factor.

We do not expect either team to be airing it out in these conditions, especially No. 10 Indiana, which runs the ball 37.9 times per game, the 42nd-most times in the FBS.

Moreover, these two defenses are some of the best that college football has to offer.

Notre Dame allows 4.4 yards allowed per play, while Indiana comes in at 4.2.

---

Betting on College Football?

• Check out the best College Football betting sites
• Read our expert’s guide on how to bet on College Football
• Get the latest College Football National Championship winner odds

---

The Fighting Irish (11-1) ranked third in the nation by allowing just 13.6 points per game, while Indiana (11-1) registered sixth by yielding 14.7 points per game.

With this game featuring two excellent defenses and potentially poor weather conditions, this one lends itself towards the Under of an already high total of 51.5.

Slam the Under here at a strong edge that could drop as weather forecasts become more clear.

PICK: Under 51.5 (-110, Fanatics)

Why Trust New York Post Betting

Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.